The Synthesis of Several 7H-Pyrrolo[2,3-d]Pyrimidin-4-amine Derivatives, Derived from Cyanobenzaldehyde, was Achieved Using Ultrasonic Waves

The Synthesis of Several 7H-Pyrrolo[2,3-d]Pyrimidin-4-amine Derivatives, Derived from Cyanobenzaldehyde, was Achieved Using Ultrasonic Waves

Authors- Sopan Tanaji Yashwantrao

Abstract-Benzaldehydes have been uswed as key intermediates in the synthesis of 7H-pyrrolo[2,3-d]pyrimidin-4-amine (PPA) derivatives. The structural identities of these newly synthesized compounds were thoroughly validated using a range of analytical techniques, including elemental analysis, infrared (IR) spectroscopy, nuclear magnetic resonance (NMR), and ultraviolet (UV) spectral data. To assess their biological activity, all of the synthesized compounds were subjected to in vitro testing to evaluate their cytotoxicity against Artemia salina. Furthermore, the antimicrobial potential of each compound was explored to determine its efficacy in inhibiting microbial growth. The antibacterial activity of these compounds was compared with that of known antibiotics, fluconazole and streptomycin, showing promising results. This study specifically emphasizes the antibacterial properties of these compounds and investigates the relationship between their chemical structure and biological activity, providing valuable insights into structure-activity relationships (SAR).

DOI: /10.61463/ijset.vol.12.issue5.388