International Journal of Science, Engineering and TechnologyAuthors: Mrs Anjali Chauhan, Dr Shraddha Upadhyay
Abstract: Aminoquinolines represent a prominent category of heterocyclic compounds that have been the focus of extensive research in recent decades due to their diverse and significant biological activities.These compounds are isomeric, distinguished by the position of the amino group on the quinoline ring, including 2-aminoquinolines, 4-aminoquinolines, and 8-aminoquinolines. They demonstrate a broad spectrum of biological activities, such as antibacterial, antimalarial, anticancer, antitumor, anti-asthmatic, and antimicrobial properties. Aminoquinolines are abundant in nature and serve as fundamental structures for the development of a wide variety of molecules in chemical sciences. This research examines recent progress in streamlined methodologies for the synthesis of diverse aminoquinoline derivatives. It also delves into their metal-binding sites and associated biological properties through a comprehensive literature review and content analysis. The results highlight the range of solvents utilized in purification techniques and their corresponding biological effects. The importance of this study lies in the variety of synthetic approaches uncovered, which may support the creation of novel compounds featuring aminoquinoline frameworks. These new compounds have the potential to exhibit enhanced bioactivity with minimized poison.
DOI: http://doi.org/10.5281/zenodo.17735888
