International Journal of Science, Engineering and TechnologyAuthors: Mr.Kundan Kale, Mr.Santosh Waghmare, Ms. Arti Chandanshive
Abstract: Oral ulcers are painful lesions of the oral mucosa that interfere with eating, speaking, and swallowing, significantly affecting quality of life. Conventional therapies, including corticosteroids, antiseptic mouthwashes, and analgesics, often provide only temporary relief and require frequent application, with the possibility of adverse effects. To overcome these limitations, the present study focuses on the development of a polyherbal mouth dissolving tablet (MDT) containing Glycyrrhiza glabra, Curcuma longa, Azadirachta indica, Aloe vera, and clove oil, selected for their anti-inflammatory, antimicrobial, antioxidant, analgesic, and wound-healing activities. The herbal extracts were subjected to phytochemical and compatibility studies before formulation. MDTs were prepared by the direct compression technique using suitable excipients and evaluated for pre-compression properties, post-compression characteristics, in vitro drug release, and antimicrobial activity against selected oral pathogens.
