International Journal of Science, Engineering and TechnologyAuthors: Sandip Thube, M. A. Badgujar
Abstract: In this study, we report the synthesis, detailed spectroscopic characterization, and antibacterial evaluation of the Schiff base ligand, 4-(Chlorobenzylidene)-2-(2-(hydroxyimino)-1,2-diphenylethylidene)hydrazine-1-carbothioamide, and its coordination complexes with selected transition metals. The ligand was synthesized via a condensation reaction and was further complexed with metal ions, including Cu(II), Ni(II), and Zn(II), under controlled conditions. Structural elucidation of both the ligand and its metal complexes was achieved using Fourier-transform infrared (FT-IR), nuclear magnetic resonance (NMR), ultraviolet-visible (UV-Vis), and mass spectroscopic techniques, with supplementary single-crystal X-ray diffraction performed for select complexes. The spectral data confirmed successful complexation, with notable shifts in functional group peaks indicating coordination between the ligand and metal ions. The antibacterial activity of the synthesized compounds was evaluated against Gram-positive and Gram-negative bacterial strains, revealing enhanced activity for the metal complexes compared to the free ligand, particularly against Escherichia coli and Staphylococcus aureus. The findings suggest that metal coordination may amplify the biological efficacy of the ligand, offering the potential for future antimicrobial drug development.
